:root {
  --blood-accent: #a33a4b;
  --blood-accent-dark: #742738;
  --blood-teal: #0d766f;
  --blood-ink: #19242d;
  --blood-wash: #f7eee9;
}

.blood-hero {
  overflow: hidden;
  background:
    radial-gradient(circle at 83% 16%, rgba(163, 58, 75, 0.2), transparent 31%),
    radial-gradient(circle at 70% 88%, rgba(13, 118, 111, 0.13), transparent 32%),
    linear-gradient(132deg, rgba(255, 253, 248, 0.98), rgba(248, 237, 232, 0.93));
}

.blood-hero::after {
  content: "";
  position: absolute;
  width: 360px;
  height: 360px;
  right: -130px;
  top: -140px;
  border: 1px solid rgba(163, 58, 75, 0.18);
  border-radius: 50%;
  box-shadow: 0 0 0 36px rgba(163, 58, 75, 0.04), 0 0 0 78px rgba(13, 118, 111, 0.03);
  pointer-events: none;
}

.blood-hero-grid {
  position: relative;
  z-index: 1;
  display: grid;
  grid-template-columns: minmax(0, 1fr);
  gap: 42px;
  align-items: end;
}

.blood-hero-grid > div {
  max-width: 980px;
}

.blood-hero h1 {
  max-width: 980px;
  color: var(--blood-ink);
}

.blood-lead {
  max-width: 820px;
  font-size: 1.05rem;
  line-height: 1.8;
}

.blood-method-stamp {
  display: grid;
  gap: 10px;
  align-self: stretch;
  align-content: end;
  padding: 26px;
  border: 1px solid rgba(116, 39, 56, 0.2);
  border-radius: 28px 28px 8px 28px;
  background: rgba(255, 253, 248, 0.76);
  box-shadow: 0 24px 50px rgba(71, 36, 42, 0.12);
}

.blood-method-stamp span {
  color: var(--blood-accent);
  font-size: 0.78rem;
  font-weight: 900;
  letter-spacing: 0.16em;
  text-transform: uppercase;
}

.blood-method-stamp strong {
  color: var(--blood-ink);
  font-size: clamp(1.35rem, 2vw, 2rem);
}

.blood-method-stamp p {
  margin: 0;
  color: #59646b;
  line-height: 1.65;
}

.blood-load-state {
  margin: 28px 0;
  padding: 18px 22px;
  border-left: 5px solid var(--blood-accent);
  color: var(--blood-ink);
  font-weight: 800;
}

.blood-load-state.is-error {
  border-left-color: #c23838;
  background: rgba(255, 238, 238, 0.95);
}

.blood-report-section {
  scroll-margin-top: 100px;
}

.blood-anchor-alias {
  display: block;
  height: 0;
  scroll-margin-top: 100px;
  visibility: hidden;
}

.blood-report-section .reveal {
  opacity: 1;
  transform: none;
}

.blood-kpi-grid {
  display: grid;
  grid-template-columns: repeat(5, minmax(0, 1fr));
  gap: 14px;
}

.blood-level-switch {
  display: inline-flex;
  gap: 6px;
  margin-bottom: 16px;
  padding: 5px;
  border: 1px solid rgba(13, 118, 111, 0.18);
  border-radius: 999px;
  background: rgba(255, 253, 248, 0.78);
}

.blood-level-switch button {
  min-height: 40px;
  padding: 0 18px;
  border: 0;
  border-radius: 999px;
  background: transparent;
  color: var(--blood-ink);
  font-weight: 900;
  cursor: pointer;
}

.blood-level-switch button.is-active {
  color: #fff;
  background: var(--blood-teal);
}

.blood-kpi {
  position: relative;
  min-height: 170px;
  padding: 22px 20px;
  border: 1px solid rgba(163, 58, 75, 0.18);
  border-radius: 22px;
  background: linear-gradient(160deg, rgba(255, 253, 248, 0.96), rgba(247, 238, 233, 0.76));
  overflow: hidden;
}

.blood-kpi::after {
  content: "";
  position: absolute;
  width: 64px;
  height: 64px;
  right: -20px;
  bottom: -20px;
  border-radius: 50%;
  background: var(--kpi-color, var(--blood-accent));
  opacity: 0.13;
}

.blood-kpi small,
.blood-kpi span {
  display: block;
}

.blood-kpi small {
  color: #687077;
  font-weight: 800;
  line-height: 1.45;
}

.blood-kpi strong {
  display: block;
  margin: 12px 0 10px;
  color: var(--kpi-color, var(--blood-accent));
  font-size: clamp(1.9rem, 3vw, 3rem);
  line-height: 1;
}

.blood-kpi span {
  color: #687077;
  font-size: 0.82rem;
  line-height: 1.45;
}

.blood-chart-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 18px;
  margin-top: 18px;
}

.blood-chart-grid-wide {
  grid-template-columns: minmax(0, 1fr);
}

.blood-pca-grid {
  grid-template-columns: repeat(2, minmax(0, 1fr));
}

.blood-panel,
.blood-table-panel {
  min-width: 0;
  padding: 22px;
}

.blood-panel h3 {
  margin: 0;
  color: var(--blood-ink);
}

.blood-panel-head {
  display: flex;
  align-items: flex-start;
  justify-content: space-between;
  gap: 18px;
}

.blood-panel-head .eyebrow {
  margin-bottom: 6px;
  color: var(--blood-accent);
}

.blood-panel-note {
  flex: 0 0 auto;
  padding: 6px 10px;
  border: 1px solid rgba(163, 58, 75, 0.16);
  border-radius: 999px;
  color: #6c4b52;
  background: rgba(247, 238, 233, 0.72);
  font-size: 0.76rem;
  font-weight: 900;
}

.blood-chart {
  width: 100%;
  min-height: 340px;
  margin-top: 8px;
}

.blood-chart-wide {
  min-height: 430px;
}

.blood-panel-span {
  grid-column: 1 / -1;
}

.blood-correlation-chart {
  min-height: 620px;
}

.blood-heatmap-note {
  margin: 12px 0;
  color: #687077;
  line-height: 1.6;
}

.blood-heatmap-layout {
  display: grid;
  grid-template-columns: 32px minmax(0, 1fr);
  gap: 8px;
  align-items: stretch;
}

.blood-heatmap-y-axis {
  display: grid;
  place-items: center;
  color: #59646b;
  font-size: 0.72rem;
  font-weight: 900;
  letter-spacing: 0.04em;
  writing-mode: vertical-rl;
  transform: rotate(180deg);
}

.blood-matrix-heatmap {
  position: relative;
  max-height: 720px;
  border: 1px solid rgba(25, 36, 45, 0.14);
  border-radius: 14px;
  background: #d9dde0;
  overflow-x: auto;
  overflow-y: auto;
}

.blood-matrix-heatmap canvas {
  display: block;
  width: 100%;
  min-width: 560px;
  image-rendering: pixelated;
}

.blood-heatmap-tooltip {
  position: fixed;
  z-index: 1000;
  max-width: 320px;
  padding: 9px 11px;
  border-radius: 10px;
  color: #fff;
  background: rgba(25, 36, 45, 0.94);
  box-shadow: 0 12px 34px rgba(25, 36, 45, 0.24);
  font-size: 0.78rem;
  line-height: 1.55;
  pointer-events: none;
}

.blood-heatmap-legend {
  display: grid;
  grid-template-columns: auto minmax(160px, 1fr) auto minmax(120px, 0.45fr);
  gap: 8px;
  align-items: center;
  margin: 12px 0 0 40px;
  color: #687077;
  font-size: 0.76rem;
}

.blood-heatmap-legend i {
  height: 10px;
  border-radius: 999px;
}

.blood-heatmap-legend i {
  background: linear-gradient(90deg, #00105e 0%, #0059b8 17%, #00bcdc 34%, #27913e 52%, #a6c400 69%, #ffdd00 85%, #ffbe2e 100%);
}

.blood-heatmap-legend em {
  font-style: normal;
  text-align: right;
}

.blood-heatmap-samples {
  display: grid;
  grid-template-columns: repeat(28, minmax(20px, 1fr));
  margin: 8px 0 0 40px;
  color: #687077;
  font-size: 0.64rem;
}

.blood-heatmap-order {
  margin: 10px 0 0 40px;
  color: #687077;
  font-size: 0.76rem;
  line-height: 1.55;
}

.blood-heatmap-samples span {
  writing-mode: vertical-rl;
  transform: rotate(180deg);
  text-align: left;
}

.blood-pca-chart {
  min-height: 510px;
}

.blood-rank-chart {
  min-height: 520px;
}

.blood-rank-tools {
  display: grid;
  grid-template-columns: minmax(240px, 1fr) auto;
  gap: 14px;
  align-items: end;
  margin-bottom: 10px;
}

.blood-rank-tools label {
  display: grid;
  gap: 6px;
  color: #59646b;
  font-size: 0.78rem;
  font-weight: 900;
}

.blood-rank-tools input {
  min-height: 44px;
  padding: 0 13px;
  border: 1px solid rgba(25, 36, 45, 0.18);
  border-radius: 12px;
  color: var(--blood-ink);
  background: rgba(255, 253, 248, 0.92);
}

.blood-rank-tools span {
  color: #687077;
  font-size: 0.82rem;
}

.blood-batch-callout {
  display: grid;
  grid-template-columns: auto 1fr auto;
  gap: 18px;
  align-items: center;
  padding: 20px 24px;
  border-color: rgba(13, 118, 111, 0.22);
  background: linear-gradient(110deg, rgba(234, 247, 243, 0.88), rgba(255, 253, 248, 0.92));
}

.blood-batch-callout strong {
  color: var(--blood-teal);
  font-size: 2rem;
}

.blood-batch-callout p {
  margin: 0;
  line-height: 1.6;
}

.blood-table-tools {
  display: grid;
  grid-template-columns: minmax(220px, 1.3fr) repeat(3, minmax(150px, 0.7fr));
  gap: 12px;
  margin-bottom: 16px;
}

.blood-table-tools-three {
  grid-template-columns: minmax(240px, 1.5fr) repeat(2, minmax(160px, 0.75fr));
}

.blood-table-tools label {
  display: grid;
  gap: 6px;
  color: #59646b;
  font-size: 0.78rem;
  font-weight: 900;
}

.blood-table-tools input,
.blood-table-tools select {
  min-height: 44px;
  width: 100%;
  padding: 0 12px;
  border: 1px solid rgba(25, 36, 45, 0.18);
  border-radius: 12px;
  background: rgba(255, 255, 255, 0.94);
  color: var(--blood-ink);
}

.blood-table-scroll {
  overflow-x: auto;
  border: 1px solid rgba(25, 36, 45, 0.12);
  border-radius: 16px;
}

.blood-table {
  width: 100%;
  min-width: 680px;
  border-collapse: collapse;
}

.blood-table th,
.blood-table td {
  padding: 13px 15px;
  border-bottom: 1px solid rgba(25, 36, 45, 0.09);
  text-align: left;
}

.blood-table th {
  background: rgba(247, 238, 233, 0.86);
  color: var(--blood-ink);
  font-size: 0.8rem;
  letter-spacing: 0.03em;
}

.blood-table td {
  color: #49555d;
}

.blood-table td:first-child {
  color: var(--blood-ink);
  font-weight: 900;
}

.blood-entity-panel,
.blood-protein-detail {
  padding: 22px;
}

.blood-entity-tabs {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
  margin-bottom: 16px;
}

.blood-entity-tabs button {
  min-height: 42px;
  padding: 0 18px;
  border: 1px solid rgba(163, 58, 75, 0.2);
  border-radius: 999px;
  background: rgba(255, 253, 248, 0.88);
  color: var(--blood-ink);
  font-weight: 900;
  cursor: pointer;
}

.blood-entity-tabs button.is-active {
  border-color: var(--blood-teal);
  color: #fff;
  background: var(--blood-teal);
}

.blood-entity-tools {
  grid-template-columns: minmax(240px, 1.4fr) repeat(3, minmax(150px, 0.7fr));
}

.blood-column-chooser {
  margin: 0 0 14px;
  border: 1px solid rgba(25, 36, 45, 0.12);
  border-radius: 14px;
  background: rgba(255, 253, 248, 0.72);
}

.blood-column-chooser summary {
  padding: 12px 14px;
  color: var(--blood-ink);
  font-weight: 900;
  cursor: pointer;
}

.blood-column-actions,
.blood-column-categories {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
  padding: 0 14px 10px;
}

.blood-column-action {
  min-height: 34px;
  padding: 0 11px;
  border: 1px solid rgba(13, 118, 111, 0.2);
  border-radius: 999px;
  background: rgba(255, 255, 255, 0.86);
  color: var(--blood-ink);
  font-size: 0.76rem;
  font-weight: 800;
  cursor: pointer;
}

.blood-column-toggle-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(180px, 1fr));
  gap: 8px;
  padding: 0 14px 14px;
}

.blood-column-toggle {
  display: flex;
  align-items: center;
  gap: 8px;
  color: #59646b;
  font-size: 0.8rem;
}

.blood-column-note {
  margin: 0;
  padding: 0 14px 12px;
  color: #687077;
  font-size: 0.76rem;
}

.blood-entity-table .blood-sort-button {
  border: 0;
  background: transparent;
  color: var(--blood-ink);
  font: inherit;
  font-weight: 900;
  cursor: pointer;
}

.blood-filter-row th {
  min-width: 132px;
  padding: 7px;
  background: rgba(248, 244, 237, 0.92);
}

.blood-column-filter {
  display: grid;
  grid-template-columns: minmax(70px, 0.72fr) minmax(70px, 1fr);
  gap: 5px;
}

.blood-column-filter select,
.blood-column-filter input {
  min-height: 34px;
  width: 100%;
  min-width: 0;
  padding: 0 7px;
  border: 1px solid rgba(25, 36, 45, 0.16);
  border-radius: 8px;
  background: #fff;
  color: var(--blood-ink);
  font-size: 0.74rem;
}

.blood-entity-table {
  min-width: 920px;
}

.blood-entity-table button {
  border: 0;
  padding: 0;
  background: transparent;
  color: var(--blood-teal);
  font: inherit;
  font-weight: 900;
  text-align: left;
  cursor: pointer;
}

.blood-entity-table button:hover,
.blood-entity-table button:focus-visible {
  color: var(--blood-accent-dark);
  text-decoration: underline;
}

.blood-protein-detail {
  margin-top: 18px;
}

.blood-protein-detail-empty {
  padding: 24px;
  color: #687077;
  text-align: center;
}

.blood-protein-head {
  display: grid;
  grid-template-columns: minmax(0, 1fr) auto;
  gap: 18px;
  align-items: start;
}

.blood-protein-head h3 {
  margin: 4px 0 8px;
  color: var(--blood-ink);
  font-size: clamp(1.45rem, 2.5vw, 2.2rem);
}

.blood-protein-head p {
  margin: 0;
  color: #59646b;
  line-height: 1.65;
}

.blood-protein-metrics {
  display: grid;
  grid-template-columns: repeat(5, minmax(0, 1fr));
  gap: 10px;
  margin: 18px 0;
}

.blood-protein-metrics div {
  padding: 13px;
  border: 1px solid rgba(25, 36, 45, 0.11);
  border-radius: 14px;
  background: rgba(247, 238, 233, 0.56);
}

.blood-protein-metrics strong,
.blood-protein-metrics span {
  display: block;
}

.blood-protein-metrics strong {
  color: var(--blood-accent);
  font-size: 1.35rem;
}

.blood-protein-metrics span {
  margin-top: 3px;
  color: #687077;
  font-size: 0.76rem;
}

.blood-sequence-block {
  margin-top: 20px;
  padding: 18px;
  border: 1px solid rgba(13, 118, 111, 0.16);
  border-radius: 18px;
  background: rgba(247, 252, 249, 0.78);
}

.blood-sequence-block h4 {
  margin: 0 0 12px;
  color: var(--blood-ink);
}

.blood-sequence-grid {
  display: grid;
  grid-template-columns: repeat(50, minmax(10px, 1fr));
  gap: 2px;
  overflow-x: auto;
  padding-bottom: 8px;
  font-family: "Cascadia Mono", "SFMono-Regular", Consolas, monospace;
  font-size: 0.72rem;
}

.blood-aa {
  display: grid;
  place-items: center;
  min-width: 12px;
  height: 22px;
  border-radius: 4px;
  color: #59646b;
  background: rgba(255, 255, 255, 0.78);
}

.blood-aa.is-covered {
  color: #fff;
  background: var(--blood-teal);
}

.blood-sequence-scale {
  display: flex;
  justify-content: space-between;
  margin-top: 8px;
  color: #687077;
  font-size: 0.76rem;
}

.blood-detail-table {
  margin-top: 18px;
}

.blood-detail-table h4 {
  color: var(--blood-ink);
}

.blood-pagination {
  display: flex;
  justify-content: space-between;
  align-items: center;
  gap: 12px;
  margin-top: 14px;
  color: #687077;
}

.blood-pagination > div {
  display: flex;
  gap: 8px;
}

.blood-pagination .button {
  min-height: 40px;
}

.blood-method-grid {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 18px;
}

.blood-requirements {
  display: grid;
  gap: 10px;
  margin-top: 18px;
}

.blood-requirement {
  display: flex;
  align-items: center;
  gap: 10px;
  padding: 10px 12px;
  border-radius: 12px;
  background: rgba(234, 247, 243, 0.76);
  color: var(--blood-ink);
  font-weight: 800;
}

.blood-requirement::before {
  content: "✓";
  display: grid;
  place-items: center;
  width: 24px;
  height: 24px;
  border-radius: 50%;
  color: #fff;
  background: var(--blood-teal);
}

.blood-definition-list {
  display: grid;
  gap: 12px;
  margin: 18px 0 0;
}

.blood-definition-list div {
  padding-bottom: 12px;
  border-bottom: 1px solid rgba(25, 36, 45, 0.1);
}

.blood-definition-list dt {
  color: var(--blood-accent-dark);
  font-weight: 900;
}

.blood-definition-list dd {
  margin: 4px 0 0;
  color: #59646b;
  line-height: 1.55;
}

body[data-theme="dark"] .blood-hero,
body[data-theme="dark"] .blood-panel,
body[data-theme="dark"] .blood-table-panel,
body[data-theme="dark"] .blood-load-state {
  color: #f8fafc;
}

body[data-theme="dark"] .blood-method-stamp,
body[data-theme="dark"] .blood-kpi,
body[data-theme="dark"] .blood-batch-callout {
  background: rgba(17, 27, 39, 0.91);
  border-color: rgba(248, 181, 192, 0.24);
}

body[data-theme="dark"] .blood-hero h1,
body[data-theme="dark"] .blood-method-stamp strong,
body[data-theme="dark"] .blood-panel h3,
body[data-theme="dark"] .blood-table td:first-child,
body[data-theme="dark"] .blood-requirement {
  color: #f8fafc;
}

body[data-theme="dark"] .blood-entity-tabs button,
body[data-theme="dark"] .blood-protein-metrics div,
body[data-theme="dark"] .blood-sequence-block {
  color: #f8fafc;
  background: rgba(17, 27, 39, 0.91);
  border-color: rgba(248, 250, 252, 0.16);
}

body[data-theme="dark"] .blood-protein-head h3,
body[data-theme="dark"] .blood-sequence-block h4,
body[data-theme="dark"] .blood-detail-table h4 {
  color: #f8fafc;
}

body[data-theme="dark"] .blood-method-stamp p,
body[data-theme="dark"] .blood-kpi small,
body[data-theme="dark"] .blood-kpi span,
body[data-theme="dark"] .blood-table td,
body[data-theme="dark"] .blood-definition-list dd {
  color: rgba(248, 250, 252, 0.75);
}

body[data-theme="dark"] .blood-table th {
  background: rgba(116, 39, 56, 0.38);
  color: #fff;
}

body[data-theme="dark"] .blood-table-tools input,
body[data-theme="dark"] .blood-table-tools select {
  background: rgba(13, 23, 35, 0.95);
  color: #fff;
  border-color: rgba(248, 250, 252, 0.22);
}

body[data-theme="dark"] .blood-requirement {
  background: rgba(13, 118, 111, 0.24);
}

body[data-theme="dark"] .blood-matrix-heatmap {
  border-color: rgba(248, 250, 252, 0.18);
  background: #3a414a;
}

@media (max-width: 1120px) {
  .blood-kpi-grid {
    grid-template-columns: repeat(3, minmax(0, 1fr));
  }
  .blood-method-grid {
    grid-template-columns: 1fr 1fr;
  }
  .blood-protein-metrics {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }
}

@media (max-width: 820px) {
  .blood-hero-grid,
  .blood-chart-grid,
  .blood-method-grid,
  .blood-table-tools {
    grid-template-columns: 1fr;
  }
  .blood-entity-tools,
  .blood-table-tools-three,
  .blood-protein-head {
    grid-template-columns: 1fr;
  }
  .blood-kpi-grid {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }
  .blood-method-stamp {
    border-radius: 20px;
  }
  .blood-pca-chart,
  .blood-chart-wide {
    min-height: 390px;
  }
  .blood-batch-callout {
    grid-template-columns: 1fr;
  }
}

@media (max-width: 520px) {
  .blood-hero h1 {
    font-size: 2.1rem;
  }
  .blood-kpi-grid {
    grid-template-columns: 1fr;
  }
  .blood-panel,
  .blood-table-panel {
    padding: 16px;
  }
  .blood-panel-head,
  .blood-pagination {
    align-items: flex-start;
    flex-direction: column;
  }
  .blood-chart {
    min-height: 320px;
  }
  .blood-rank-tools {
    grid-template-columns: 1fr;
  }
  .blood-heatmap-legend {
    grid-template-columns: auto minmax(0, 1fr) auto;
    margin-left: 0;
  }
  .blood-heatmap-legend em {
    grid-column: 1 / -1;
    text-align: left;
  }
}