Biognosys iRT Standard 安全数据表（英文，2023）

Safety Data Sheet according to Regulation (EC) No. 1907/2006 (REACH) iRT Standard Print date 25.08.2023 Revision date 25.08.2023 Version 1.0 (en,US) SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1 Product identifier Trade name/designation iRT Standard 1.2 Relevant identified uses of the substance or mixture and uses advised against Use of the substance/mixture Laboratory chemical 1.3 Details of the supplier of the safety data sheet Supplier Biognosys AG Wagistrasse 21 CH-8952 Schlieren Telephone +41 44 7382040 Website https://biognosys.com/ Department responsible for information: Telephone +41 44 7382040 Manufacturer 1.4 Emergency telephone number England, Wales and Scotland dial: 111; Republic of Ireland dial: 01 809 2166 Biognosys AG +41 44 7382040 Only available during office hours. SECTION 2: Hazards identification 2.1 Classification of the substance or mixture Remark The mixture is classified as not hazardous according to regulation (EC) No 1272/2008 [CLP]. The product does not require labelling according to Regulation (EC) No 1272/2008 [GHS]. 2.2 Label elements No data available 2.3 Other hazards Results of PBT and vPvB assessment The substances in the mixture do not meet the PBT/vPvB criteria according to REACH, annex XIII. SECTION 3: Composition / information on ingredients 3.1 Substances not applicable 3.2 Mixtures Additional information Peptide mixture, lyophilised Biognosys AG - Wagistrasse 21 - CH-8952 Schlieren Page 1 of 9

Safety Data Sheet according to Regulation (EC) No. 1907/2006 (REACH) iRT Standard Print date 25.08.2023 Revision date 25.08.2023 Version 1.0 (en,US) Remark The mixture does not contain hazardous materials to be mentioned here. SECTION 4: First aid measures 4.1 Description of first aid measures General information Remove contaminated, saturated clothing immediately. In case of occurring and / or persistent complaints consult a doctor. Following inhalation Remove casualty to fresh air and keep warm and at rest. In the event of symptoms refer for medical treatment. Following skin contact Wash immediately with: Water In case of skin reactions, consult a physician. After eye contact Rinse immediately carefully and thoroughly with eye-bath or water. Remove contact lenses. In case of eye irritation consult an ophthalmologist. Following ingestion Do NOT induce vomiting. Rinse mouth thoroughly with water. In the event of symptoms seek medical treatment. 4.2 Most important symptoms and effects, both acute and delayed No data available 4.3 Indication of any immediate medical attention and special treatment needed No data available SECTION 5: Firefighting measures 5.1 Extinguishing media Suitable extinguishing media alcohol resistant foam Dry extinguishing powder Carbon dioxide (CO2) Water spray jet 5.2 Special hazards arising from the substance or mixture Hazardous combustion products In the case of thermal decomposition formation of dangerous gases possible. 5.3 Advice for firefighters Special protective equipment for firefighters In case of fire: Wear self-contained breathing apparatus. Protective clothing. Biognosys AG - Wagistrasse 21 - CH-8952 Schlieren Page 2 of 9

Safety Data Sheet according to Regulation (EC) No. 1907/2006 (REACH) iRT Standard Print date 25.08.2023 Revision date 25.08.2023 Version 1.0 (en,US) Additional information Fire residues and contaminated firefighting water must be disposed of in accordance with the local regulations. Collect contaminated fire extinguishing water separately. Do not allow entering drains or surface water. SECTION 6: Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures For non-emergency personnel Provide adequate ventilation. Avoid dust formation. Use personal protection equipment. Wear breathing apparatus if exposed to vapours/dusts/aerosols. Avoid skin and eye contact. 6.2 Environmental precautions Do not allow to enter into surface water or drains. Do not allow to enter into soil/subsoil. If the product contaminates soil, waterways or drains inform the corresponding authorities. 6.3 Methods and material for containment and cleaning up For containment Ensure adequate ventilation. After taking up the material dispose according to regulation. Take up mechanically and send for disposal. Flush away residues with water. 6.4 Reference to other sections Safe handling: see section 7 Disposal: see section 13 Personal protection equipment: see section 8 Emergency telephone number: see section 1 SECTION 7: Handling and storage 7.1 Precautions for safe handling Protective measures Dust formation, which can not be avoided, take up regularly. Do not inhale dusts. Avoid the formation of dust. If local exhaust ventilation is not possible or not sufficient, the entire working area should be ventilated by technical means. Usual measures for fire prevention. Avoid: Eye contact Skin contact Do not inhale dust. Advices on general occupational hygiene Thorough skin-cleansing after handling the product. Apply skin care products after work. Make available sufficient washing facilities When using do not eat, drink, smoke, sniff. Remove contaminated, saturated clothing immediately. Biognosys AG - Wagistrasse 21 - CH-8952 Schlieren Page 3 of 9

Safety Data Sheet according to Regulation (EC) No. 1907/2006 (REACH) iRT Standard Print date 25.08.2023 Revision date 25.08.2023 Version 1.0 (en,US) 7.2 Conditions for safe storage, including any incompatibilities Requirements for storage rooms and vessels Keep/Store only in original container. Keep container tightly closed. Storage class 11 Combustible solids that cannot be assigned to any of the above storage classes Materials to avoid Do not store together with: Food and feedingstuffs Further information on storage conditions Keep container dry and store at a cool place. 7.3 Specific end use(s) No data available SECTION 8: Exposure controls/personal protection 8.1 Control parameters No data available 8.2 Exposure controls Appropriate engineering controls Technical measures to prevent exposure Ensure good ventilation, where necessary use fume hood. Personal protection equipment Eye/face protection Suitable eye protection: Eye glasses For eye protection, use only equipment that has been tested and approved to regulatory standards such as NIOSH (US) or EN 166 (EU). Hand protection The selection of the suitable gloves does not only depend on different material, but also on further marks of quality and varies from manufacturer to manufacturer. Suitable gloves type NR (natural rubber, natural latex) NBR (Nitrile rubber) The exact breakthrough time of the glove material can be requested from the protective glove manufacturer and must be observed. The selected protective gloves have to comply with the specifications of EC directive 89/686/EEC and the resultant standard EN374. Body protection: Protective clothing Respiratory protection In case of dust formation wear micro dust mask. Suitable respiratory protection apparatus: Short term: filter apparatus, Filter P1 Atemschutzmasken und Komponenten müssen gemäß den entsprechenden staatlichen Standards wie NIOHS (US) oder CEN (EU) getestet und zugelassen werden. Biognosys AG - Wagistrasse 21 - CH-8952 Schlieren Page 4 of 9

Safety Data Sheet according to Regulation (EC) No. 1907/2006 (REACH) iRT Standard Print date 25.08.2023 Revision date 25.08.2023 Version 1.0 (en,US) SECTION 9: Physical and chemical properties 9.1 Information on basic physical and chemical properties Physical state solid / lyophilized Safety relevant basis data Value Method Source, Remark Odour threshold: not determined Melting point/freezing point not determined Boiling point or initial boiling point and boiling range not determined flammability not determined Lower and upper explosion limit not determined Flash point not determined Auto-ignition temperature not determined Decomposition temperature not determined pH not determined Viscosity not determined Solubility(ies) not determined Partition coefficient n- octanol/water (log value) not determined Vapour pressure not determined Density and/or relative density not determined Relative vapour density not determined particle characteristics not determined 9.2 Other information No data available SECTION 10: Stability and reactivity 10.1 Reactivity No data available 10.2 Chemical stability The product is chemically stable under recommended conditions of storage, use and temperature. 10.3 Possibility of hazardous reactions No data available 10.4 Conditions to avoid No data available 10.5 Incompatible materials Oxidising agent 10.6 Hazardous decomposition products Concerning possible decomposition products see section 5. Biognosys AG - Wagistrasse 21 - CH-8952 Schlieren Page 5 of 9

Safety Data Sheet according to Regulation (EC) No. 1907/2006 (REACH) iRT Standard Print date 25.08.2023 Revision date 25.08.2023 Version 1.0 (en,US) Additional information As a general rule we recommend avoiding the contact with strong chemical reagents, such as acids, bases, reductors and oxidizers. SECTION 11: Toxicological information 11.1 Information on hazard classes as defined in Regulation (EC) No 1272/2008 Acute toxicity Animal data Effective dose Method,Evaluation Source, Remark Acute oral toxicity not determined Acute dermal toxicity not determined Acute inhalation toxicity not determined Skin corrosion/irritation Assessment/classification No irritant effect known. Serious eye damage/irritation Assessment/classification No irritant effect known. Sensitisation to the respiratory tract Assessment/classification No sensitizing effects known. Skin sensitisation Assessment/classification No sensitising effect known. Germ cell mutagenicity not determined Carcinogenicity not determined Reproductive toxicity not determined STOT-single exposure not determined STOT-repeated exposure not determined Aspiration hazard Remark No danger of aspiration according to CLP Regulation. 11.2 Information on other hazards Symptoms related to the physical, chemical and toxicological characteristics Biognosys AG - Wagistrasse 21 - CH-8952 Schlieren Page 6 of 9

Safety Data Sheet according to Regulation (EC) No. 1907/2006 (REACH) iRT Standard Print date 25.08.2023 Revision date 25.08.2023 Version 1.0 (en,US) Effective dose Method,Evaluation Source, Remark Endocrine disrupting properties Based on available data, the classification criteria are not met. Other information The product should be handled with the care usual when dealing with chemicals. Further hazardous properties can not be excluded. SECTION 12: Ecological information 12.1 Toxicity Aquatic toxicity Effective dose Method,Evaluation Source, Remark Acute (short-term) fish toxicity not determined Chronic (long-term) fish toxicity not determined Acute (short-term) toxicity to crustacea not determined Chronic (long-term) toxicity to aquatic invertebrate not determined Acute (short-term) toxicity to algae and cyanobacteria not determined Chronic (long-term) toxicity to aquatic algae and cyanobacteria not determined Toxicity to other aquatic plants/organisms not determined Toxicity to microorganisms not determined 12.2 Persistence and degradability No data available 12.3 Bioaccumulative potential No data available 12.4 Mobility in soil No data available 12.5 Results of PBT and vPvB assessment The substances in the mixture do not meet the PBT/vPvB criteria according to REACH, annex XIII. 12.6 Endocrine disrupting properties Effective dose Method,Evaluation Source, Remark Endocrine disrupting properties Based on available data, the classification criteria are not met. 12.7 Other adverse effects Additional ecotoxicological information Additional information Ecological dates are not available. Product is not allowed to be discharged into aquatic environment, drains or sewage treatment plants. Biognosys AG - Wagistrasse 21 - CH-8952 Schlieren Page 7 of 9

Safety Data Sheet according to Regulation (EC) No. 1907/2006 (REACH) iRT Standard Print date 25.08.2023 Revision date 25.08.2023 Version 1.0 (en,US) SECTION 13: Disposal considerations 13.1 Waste treatment methods Appropriate disposal / Product Dispose of waste according to applicable legislation. - Appropriate disposal / Package Disposal in accordance with local regulations. Remark The allocation of waste identity numbers/waste descriptions must be carried out according to the EEC, specific to the industry and process. SECTION 14: Transport information Land transport (ADR/RID) Sea transport (IMDG) Air transport (ICAO-TI / IATA-DGR) 14.1 UN number or ID number - - - 14.2 UN proper shipping name - - - 14.3 Transport hazard class(es) - - - 14.4 Packing group - - - 14.5 Environmental hazards - - - 14.6 Special precautions for user No data available 14.7 Maritime transport in bulk according to IMO instruments No data available All transport carriers Protect from moisture. No dangerous good in sense of these transport regulations. SECTION 15: Regulatory information 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture No data available 15.2 Chemical Safety Assessment No data available SECTION 16: Other information Indication of changes * Data changed compared with the previous version Biognosys AG - Wagistrasse 21 - CH-8952 Schlieren Page 8 of 9

Safety Data Sheet according to Regulation (EC) No. 1907/2006 (REACH) iRT Standard Print date 25.08.2023 Revision date 25.08.2023 Version 1.0 (en,US) Abbreviations and acronyms For abbreviations and acronyms, see: ECHA Guidance on information requirements and chemical safety assessment, chapter R.20 (Table of terms and abbreviations). CLP: Classification, Labelling and Packaging ECHA: European Chemicals Agency GHS: Globally Harmonized System of Classification and Labelling of Chemicals REACH: Registration, Evaluation and Authorization of Chemicals ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road IATA: International Air Transport Association IMDG: International Maritime Dangerous Goods PBT: persistent and bioaccumulative and toxic vPvB: very persistent, very bioaccumulative SVHC: Substance of Very High Concern WGK: water hazard class See overview table at www.euphrac.eu Key literature references and sources for data Data sheets of the sub-supplier. Classification for mixtures and used evaluation method according to regulation (EC) No 1272/2008 [CLP] The classification of the mixture was carried out following the calculation method according to the CLP Regulation (1272/2008). Additional information National and local regulations concerning chemicals shall be observed. The national special regulations must be implemented by each user on his own responsibility! The above information describes exclusively the safety requirements of the product and is based on our present-day knowledge. The information is intended to give you advice about the safe handling of the product named in this safety data sheet, for storage, processing, transport and disposal. The information cannot be transferred to other products. In the case of mixing the product with other products or in the case of processing, the information on this safety data sheet is not necessarily valid for the new made-up material. Please observe the following disclaimer! Our safety data sheets have been compiled according to effective EU directives, WITHOUT taking into account the special national directives concerning the handling of hazardous substances. Biognosys AG - Wagistrasse 21 - CH-8952 Schlieren Page 9 of 9