从修饰到MHC，Biognosys产品2021年高分文章导读
新的一年，DIA技术深入人心，得到了广泛的应用，让我们来看看各个领域的专家们是如何应用我们的产品产出新的科学成果的吧。
Mapping Protein Carboxymethylation Sites Provides Insights into their Role in Proteostasis and Cell Proliferation
Di Sanzo S. et al., Nature Communications 2021
文章链接：https://www.nature.com/articles/s41467-021-26982-6
MhcVizPipe: A Quality Control Software for Rapid Assessment of Small- to Large-Scale Immunopeptidome Data Sets
Kovalchik K.A. et al., MCP 2021
文章链接：https://www.mcponline.org/article/S1535-9476(21)00150-X/fulltext
Reproducible Determination of High-Density Lipoprotein Proteotypes
Goetze S. et al., Journal of Proteome Research 2021
文章链接：https://pubs.acs.org/doi/10.1021/acs.jproteome.1c00429
DIA-Based Proteome Profiling of Nasopharyngeal Swabs from COVID-19 Patients
Mun D. et al., Journal of Proteome Research 2021
文章链接：https://pubs.acs.org/doi/10.1021/acs.jproteome.1c00506
Molecular Characterization of Hematopoietic Stem Cells after in Vitro Amplification on Biomimetic 3D PDMS Cell Culture Scaffolds
Marx-Blümel L. et al., Scientific Reports 2021
文章链接：https://www.nature.com/articles/s41598-021-00619-6
Unravelling the Ubiquitination of Circadian Clock Proteins with Spectronaut
Fynn M. Hansen F.M. et al., Nature Communications 2021
Deep Characterization of the HLA Immunopeptidome with Spectronaut
Pak S. et al., MCP 2021
文章链接：https://www.mcponline.org/article/S1535-9476(21)00053-0/fulltext
Potential Targets to Treat Drug-resistant Tumors Uncovered with Spectronaut’s directDIA Phosphoproteomics Workflow
Franciosa G. et al., Nature Communications 2021
文章链接：https://www.nature.com/articles/s41467-021-22787-9
Investigating Age-dependent Changes in Muscle Stem Cell Functionality with Spectronaut and SpectroDive
Schüler S.C. et al., Cell Reports 2021
文章链接：https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00574-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS221112472100574X%3Fshowall%3Dtrue
Multi-omics Investigation of Daily Exercise Performance with SpectroMine
Maier G. et al., The Journal of Physiology 2021
文章链接：https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP281535
肌肉活动被认为受生物钟调节，同时作为上游 Zeitgeber 同步肌肉和其他外周组织的生理和分子反应。这里作者采用多组学方法来研究耐力表现的昼夜节律调节和运动对昼夜节律钟的控制。作者在 SpectroMine 中对带有TMT 标签标记的磷酸化和总蛋白质组进行定量分析。这项研究为识别和验证运动表现的标志物提供了一个起点，可能有助于个性化的训练设计和患者护理。
相关阅读：
SpectroDive--专门为靶向蛋白质组学技术（ PRM和MRM）的数据分析而开发的软件