---
title: "悟空云数据分析交流第三期 之假设检验"
author: "omicsolution"
account: "omicsolution"
published_at: "2020-09-24T16:59:08+08:00"
captured_at: "2026-08-26T17:51:05.814010+08:00"
source_url: "https://mp.weixin.qq.com/s/G8Usxtnw9iYfSbuXy1ae4A"
---

# 悟空云数据分析交流第三期 之假设检验
如何进行假设检验，换句话说如何筛选差异蛋白一直是让人个头疼的问题，绵延n年也没个非常权威的做法，本期悟空云数据分析交流诗盛将就此和大家聊聊他的看法和做法。如果对于如何检验需要刨根问底的话，那欢迎加QQ群 688728477 继续讨论。

目前基于悟空平台开发的分析工具已发表以下文章：

NAguideR模块：

(2020) Shisheng Wang , Wenxue Li, Liqiang Hu, Jingqiu Cheng, Hao Yang, Yansheng Liu, NAguideR: performing and prioritizing missing value imputations for consistent bottom-up proteomic analyses, Nucleic Acids Research, gkaa498. (IF: 11).

motifeR模块：

(2019) Shisheng Wang , Yue Cai, Jingqiu Cheng, Wenxue Li, Yansheng Liu and Hao Yang. motifeR: An Integrated Web Software for Identification and Visualization of Protein Post‐Translational Modification Motifs. Proteomics: 201900245. (IF: 3).

pseudoQC模块：

(2019) Shisheng Wang and Hao Yang. pseudoQC: A Regression‐Based Simulation Software for Correction and Normalization of Complex Metabolomics and Proteomics Datasets. Proteomics: 1900264. (IF: 3).

MetaboGroupS模块：

(2018) Shisheng Wang , ..., and Meng Gong. MetaboGroupS: A Group Entropy-Based Web Platform for Evaluating Normalization Methods in Blood Metabolomics Data from Maintenance Hemodialysis Patients. Anal Chem 90, 11124-11130. (IF: 6).

MixProTool模块：

(2018) Shisheng Wang , ..., and Hao Yang. MixProTool: A Powerful and Comprehensive Web Tool for Analyzing and Visualizing Multigroup Proteomics Data. Journal of computational biology : a journal of computational molecular cell biology 25, 1123-1127. (IF: 1).

![图片 1](images/001.png)

同时悟空平台整合上百个分析模块，包括且远不止以下功能

![图片 2](images/002.png)

而围绕上游质谱数据解析和下游组学应用，易算近期也发表了多篇文章：

(2020)Yi Yang, ..., and Liang Qiao In silico spectral libraries by deep learning facilitate data-independent acquisition proteomics. Nature Communications

https://doi.org/10.1038/s41467-019-13866-z (IF:13)

(2020）Shuping Long, ..., Liang Qiao Metaproteomics characterizes human gut microbiome function in colorectal cancer. npj Biofilms and Microbiomes

https://doi.org/10.1038/s41522-020-0123-4 (IF: 18)

(2020) Rutan Zhang, ..., Liang Qiao Proteomic and Metabolic Elucidation of Solar-Powered Biomanufacturing by Bio-Abiotic Hybrid System.

https://doi.org/10.1016/j.chempr.2019.11.002 (IF:5)

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