---
title: "SpectroDive功能升级历史（截止22.11）"
author: "omicsolution"
account: "omicsolution"
published_at: "2025-04-09T11:26:09+08:00"
captured_at: "2026-08-27T10:51:44.321770+08:00"
source_url: "https://mp.weixin.qq.com/s?__biz=MzI2MTI5NDAzNg==&mid=2247490394&idx=1&sn=d11190875a8334365ab181a69e507696&chksm=ea5dc9e1dd2a40f73c5f14e19cb31f0409167fc5ff7e1cf4c70026af8ec6ff7022ca05c272ee#rd"
---

# SpectroDive功能升级历史（截止22.11）
![图片 1](images/001.png)

[Update 11.3.221103.47784]

- Added calibration curve linear fit descriptors

- Disabling clustering when there is not enough data points

[Update 11.2.221014.47784]

- Removed multiplexed information in Thermo QExactive instrument method output

- Allow deselection of "Show Legend" in MS1/MS2 Alignment plots

[Update 11.1.220930.47784]

- Added -command option to command-line interface

大版本升级[SpectroDive 11 - Release Notes]

New Absolute Quantification Workflow

- Creation and visualization of calibration curves

- Determination of limits of detection (LOD) and of quantification (LLOQ, ULOQ)

- Quantification of samples using calibration curves

Ion Mobility Support

- FAIMS-PRM: analysis and method export

- prm-PASEF: analysis and method export

Support for New Acquisition Methods

- Hybrid-DIA: analysis and method export for targeted peptides

Improved Performance

- Improved peak picking

- Improved Pulsar search engine for panel generation

Improved User Experience and Visualization

- Improved XIC Alignment plots with support for unlimited number of runs

- Detachable perspective and plots for side-by-side visualization

- Improved XIC grid overview plots

- One-Click tree navigation in plots

- Improved plot and tree filter selection

- Quick-Action bar for analysis perspective

- Improved UI for analysis log

- New prm-PASEF mobilogram plot

- Streamlined settings for clarity with new advanced category

- Switched to a 2-color system for identification status annotation

[Update 10.7.220414.47784]

- Added saved experiment SPE saving from CLI

- Allow loading a settings schmema from name or file path in CLI

- Implemented quantity correction from samples conditions setup

[Update 10.6.220225.47784]

- Calculating number of removed assays in MRM

- Automatic upgrade and/or warning to save to new SPE file standard

[Update 10.5.211227.47784]

- Added scores for library fragments in refinement window

- Consistent date/time format for iRT calibration runs

[Update 10.3.210226.47784]

- Significant improvement in RAM requirement

- Changed default strategy for summarizing multiple survey runs by taking an average across peptide, instead of lowest

- Updated manual

[Update 10.2.210120.47784]

- Clean up of temporary files was not happening after closing a SureQuant experiment

- Improved loading performance for search archives using Pulsar for library generation

- Added unpaired t-test strategy and made it default for regulation analysis

- Improved fall back tolerances if automatic mass calibration did not have enough data points

- New default option for spike-in workfow which requires identification of both target and reference channels

大版本升级[SpectroDive 10 - Release Notes]

Full Support for SureQuant Analysis

- Support for method development for custom panels

- Seamless data analysis with optimized peak picking for SureQuant acquisition

- Post Analysis plots specifically for SureQuant acquisition

Improved False Discovery Rate Analysis

- New decoy strategy for PRM and SureQuant

- Reliable and automatic FDR for MRM, PRM and SureQuant analysis

Improved Performance

- SpectroDive uses up to 30% less RAM than before

Library based PRM Scheduling

- Import iRT calibration directly from a DDA or DIA spectral library for scheduling

- Support for non-linear gradients

Improved Panel Support

- Improved support for panel generation from library

- Improved support for modifying an existing panel

- Support for refining assays directly from a targeted analysis

- Improved GUI for refining iRT and fragment selection

Library Generation

- View library settings in library perspective (for new libraries only)

- Improved identifications from deep learning augmented scoring with Pulsar

- Added PD 2.4 support

Other Features

- New global settings for setting up SureQuant acquisition from a survey run

- Mono-isotopic MS1 quantity is now reported for PRM and SureQuant

- SpectroDive Viewer is available for browsing of already analyzed experiments

- Various minor improvements in user experience

[Update 9.10.190923.41419]

- Added interference score for transitions in the report perspective

[Update 9.6.190725.41419]

- Added skip to last option for external panel import in prepare perspective to easily import panel as it is

[Update 9.5.190416.41419]

- Added support for fill time correction in multipexed PRM

[Update 9.1.190401.41419]

- Added ability to sort runs by different criterias such as acqusition date, condition, etc.

大版本升级What is new in SpectroDive 9.0?

- Improved panel generation workflow starting from spectral library

- Support for non-linear gradient based inclusion list scheduling

- Support for DDA or DIA based inclusion list scheduling

- Improved PRM data analysis by using MS1 information

- Pulsar database search engine integration

- PQ500 human plasma panel support

- MaxQuant.Live support

- Improved wizard based experiment setup

- Improved performance and memory management

[Bug Fixes 8.0.14288.5]

- Switched to new MassLynxRawSDK API for Waters MRM data

[Bug Fixes 8.0.14288.4]

- Improved scaling for mirrored XIC chart in alignment view

[Bug Fixes 8.0.14288.3]

- Added support to specify panel when setting up an experiment from command line prompt

[Bug Fixes 8.0.14288.1]

- Added support for Xcalibur 4.0 method export

- Added support for Fusion PRM

大版本升级What is new in SpectroDive 8.0?

- Library generation from DDA results

- MRM / PRM panel generation from library

- Fragment ion refinement for PRM panels

- Improved performance for PRM

- Improved memory management

- Improved cache management

- Improved performance for loading / saving SPE files

- On-Click integration in XIC plots

- Data-completeness plot in post analysis

- CVs below X plot in post analysis

- Experiment overview grid in post analysis

- MS2 scan at apex plot for PRM

- Improved workflow for mixed analysis (MRM and PRM)

- Improved modification management

- Improved UI scalability

[Update 7.5.10300.4]

- Improved panel matching

- Minor bug fixes and improvements

大版本升级[Release Notes]What is new in SpectroDive 7.5?

- Support for Agilent instruments

- Improved performance for PRM workflows

- iRT refinement for PRM panels

- Miscellaneous minor bug fixes and improvements