---
title: "SpectroDive功能升级历史（截止24.06）"
author: "omicsolution"
account: "omicsolution"
published_at: "2025-04-09T11:26:09+08:00"
captured_at: "2026-08-27T10:51:43.785196+08:00"
source_url: "https://mp.weixin.qq.com/s?__biz=MzI2MTI5NDAzNg==&mid=2247495108&idx=1&sn=1d7da009b393cfd7a1074e892e346183&chksm=ea5e3f7fdd29b669e998355f93cc180ffb3b0a4ad038cbbc3f8ae57bb028ee77de8d8341a364#rd"
---

# SpectroDive功能升级历史（截止24.06）
![图片 1](images/001.png)

[更新 11.14.240618.47784]

- 允许在删除或排除片段后重新计算 Q 值

- 排除片段时防止应用程序冻结

- 添加新的报告字段 PEP.AbsoluteAmount、PG.AbsoluteAmount 和 EG.AbsoluteQuantificationMethod

- 以线性比例添加新的报告字段 R.FileSize (MB) 和 R.MS1TIC

- 添加新的报告字段 E.IdentificationStrategy 和 E.IdentificationThreshold

- 增加前体和多肽数量折叠的最大选项

- 允许在样品定量实验中报告校准曲线限值（LOD、LLOQ、ULOQ

- 提示用户在执行片段选择细化之前重新提取原始 SureQuant 数据

[更新 11.13.240131.47784］

- 允许 TimsTOF Pro 仪器导出 PRM 方法

- 修正了分析后条件设置中错误的数量校正因子

- 防止在样品定量后分析步骤中重新计算校准曲线

- 修正了更改 XIC 边界时校准曲线图消失的问题

- 修复了基于参照的工作流程中过渡干扰得分缺失的问题

- 修复了在报告视角中输出绝对量时忽略用户接受的错误

- 修复了沃特斯 MRM 支持

[更新 11.12.231212.47784］

- 修复了 11.12 中引入的错误，即没有处理校准曲线

[更新 11.12.231207.47784］

- 修正了 QValue 报告中的差异

- 为定标曲线图添加选项，以移除局部定量

- 为校准曲线图添加选项，将 X 轴显示改为线性

- 为校准曲线图添加选项，以移除标题中的定量范围

- 修正了在校准曲线处理实验中，分析后更改设置会导致校准曲线平坦的错误

- 使适用于分析后的设置可在分析后编辑

[更新 11.11.231110.47784］

- 修复了某些情况下的软件激活问题

[更新 11.11.231018.47784］

- 修复了离线激活的问题

- 修复了 “分析后 ”视角中 “X ”以下 Cvs 图的缩放问题

- 修复了 “分析 ”视角中缺失的 “采集概览 ”图

[小更新 11.10.230428.47784］

- 修复了许可证过期系统的启动崩溃问题

[更新 11.9.230425.47784］

- 将 .NET 版本从 5.0 更新至 6.0

- 修复了从库校准工作流程中峰值容量和 FWHM 丢失的问题

[更新 11.8.230330.47784］

- 修复了使用 Pulsar 生成库过程中的装配缺失错误

[更新 11.7.230316.47784］

- 修正了高 DPI 系统中罕见的启动问题

- 修正了较重元素 (> 氩) 质量表中的错误 (0.0 质量)

- 修正了羟脯氨酸的定义

- 修正了在修改面板中显示元素周期表的问题

- 修正了校准曲线图的类别

- 修正了多个实验的信息显示在错误的分析日志中的问题

- 修复了 “准备 ”视角中 RT 校准消失的问题

- 修复了创建 FAIMS-SureQuant 仪器方法时的罕见故障

- 修复了在创建 FAIMS-SureQuant 仪器方法时出现的罕见故障

- 添加了校准曲线特定的可报告元素

- 新增 Pulsar 设置，将所有运行视为同一样本的馏分来生成文库

- 点击校准曲线图点显示信息而不是悬停

改进面板生成向导：

- 改进状态信息

- 根据所有出现的蛋白质而非蛋白质推断进行蛋白质分组的新设置

- 根据其他 FASTA 文件检查肽序列的新功能

- 改进了分馏样本光谱库中肽段的丰度排序

- 新增特定基因筛选和多肽分组功能

- 添加了基于序列和蛋白质内位置的广泛肽段过滤功能

[更新 11.6.230131.47784］

- 修复了空的 MS1/MS2 XIC 对齐图

[更新 11.5.221221.47784］

- 确保导入或创建化验面板时显示在树形视图中

- 修复了读取未计划的 prm-PASEF 文件的错误

- 修复了在检测面板信息不完整的情况下丢失交叉运行图的错误

[更新 11.4.221128.47784］

- 在 “运行 ”概览中显示正确的已确认化验数量

- 修正了参比肽序列稀释校准曲线处理中的错误

- 修复了 “分析 ”视角树形视图中显示已删除检测的错误

- 在分析视角中添加了黄色条

- 在使用不含离子迁移率信息的化验面板分析 prm-PASEF 数据时添加了警告功能

- 在使用不含离子迁移率信息的检测面板分析 prm-PASEF 数据时添加了警告功能

- 添加了对 FAIMS-SureQuant 的支持（分析文件和仪器方法导出）

- 允许使用无空白的连续稀释数据处理校准曲线 - LOD 不可用

- 修复用于布鲁克 TimsTOF 的 prm-PASEF 仪器方法导出中的错误

- 修复定标曲线图与定量范围显示不正确的问题

- 支持未计划的 prm-PASEF 仪器方法导出

- 为基于定标曲线的绝对定量添加了量校正因子支持

- 关闭校准曲线处理之外的校准曲线描述符报告

[Update 11.3.221103.47784]

- Added calibration curve linear fit descriptors

- Disabling clustering when there is not enough data points

[Update 11.2.221014.47784]

- Removed multiplexed information in Thermo QExactive instrument method output

- Allow deselection of "Show Legend" in MS1/MS2 Alignment plots

[Update 11.1.220930.47784]

- Added -command option to command-line interface

大版本升级[SpectroDive 11 - Release Notes]

New Absolute Quantification Workflow

- Creation and visualization of calibration curves

- Determination of limits of detection (LOD) and of quantification (LLOQ, ULOQ)

- Quantification of samples using calibration curves

Ion Mobility Support

- FAIMS-PRM: analysis and method export

- prm-PASEF: analysis and method export

Support for New Acquisition Methods

- Hybrid-DIA: analysis and method export for targeted peptides

Improved Performance

- Improved peak picking

- Improved Pulsar search engine for panel generation

Improved User Experience and Visualization

- Improved XIC Alignment plots with support for unlimited number of runs

- Detachable perspective and plots for side-by-side visualization

- Improved XIC grid overview plots

- One-Click tree navigation in plots

- Improved plot and tree filter selection

- Quick-Action bar for analysis perspective

- Improved UI for analysis log

- New prm-PASEF mobilogram plot

- Streamlined settings for clarity with new advanced category

- Switched to a 2-color system for identification status annotation

[Update 10.7.220414.47784]

- Added saved experiment SPE saving from CLI

- Allow loading a settings schmema from name or file path in CLI

- Implemented quantity correction from samples conditions setup

[Update 10.6.220225.47784]

- Calculating number of removed assays in MRM

- Automatic upgrade and/or warning to save to new SPE file standard

[Update 10.5.211227.47784]

- Added scores for library fragments in refinement window

- Consistent date/time format for iRT calibration runs

[Update 10.3.210226.47784]

- Significant improvement in RAM requirement

- Changed default strategy for summarizing multiple survey runs by taking an average across peptide, instead of lowest

- Updated manual

[Update 10.2.210120.47784]

- Clean up of temporary files was not happening after closing a SureQuant experiment

- Improved loading performance for search archives using Pulsar for library generation

- Added unpaired t-test strategy and made it default for regulation analysis

- Improved fall back tolerances if automatic mass calibration did not have enough data points

- New default option for spike-in workfow which requires identification of both target and reference channels

大版本升级[SpectroDive 10 - Release Notes]

Full Support for SureQuant Analysis

- Support for method development for custom panels

- Seamless data analysis with optimized peak picking for SureQuant acquisition

- Post Analysis plots specifically for SureQuant acquisition

Improved False Discovery Rate Analysis

- New decoy strategy for PRM and SureQuant

- Reliable and automatic FDR for MRM, PRM and SureQuant analysis

Improved Performance

- SpectroDive uses up to 30% less RAM than before

Library based PRM Scheduling

- Import iRT calibration directly from a DDA or DIA spectral library for scheduling

- Support for non-linear gradients

Improved Panel Support

- Improved support for panel generation from library

- Improved support for modifying an existing panel

- Support for refining assays directly from a targeted analysis

- Improved GUI for refining iRT and fragment selection

Library Generation

- View library settings in library perspective (for new libraries only)

- Improved identifications from deep learning augmented scoring with Pulsar

- Added PD 2.4 support

Other Features

- New global settings for setting up SureQuant acquisition from a survey run

- Mono-isotopic MS1 quantity is now reported for PRM and SureQuant

- SpectroDive Viewer is available for browsing of already analyzed experiments

- Various minor improvements in user experience

[Update 9.10.190923.41419]

- Added interference score for transitions in the report perspective

[Update 9.6.190725.41419]

- Added skip to last option for external panel import in prepare perspective to easily import panel as it is

[Update 9.5.190416.41419]

- Added support for fill time correction in multipexed PRM

[Update 9.1.190401.41419]

- Added ability to sort runs by different criterias such as acqusition date, condition, etc.

大版本升级What is new in SpectroDive 9.0?

- Improved panel generation workflow starting from spectral library

- Support for non-linear gradient based inclusion list scheduling

- Support for DDA or DIA based inclusion list scheduling

- Improved PRM data analysis by using MS1 information

- Pulsar database search engine integration

- PQ500 human plasma panel support

- MaxQuant.Live support

- Improved wizard based experiment setup

- Improved performance and memory management

[Bug Fixes 8.0.14288.5]

- Switched to new MassLynxRawSDK API for Waters MRM data

[Bug Fixes 8.0.14288.4]

- Improved scaling for mirrored XIC chart in alignment view

[Bug Fixes 8.0.14288.3]

- Added support to specify panel when setting up an experiment from command line prompt

[Bug Fixes 8.0.14288.1]

- Added support for Xcalibur 4.0 method export

- Added support for Fusion PRM

大版本升级What is new in SpectroDive 8.0?

- Library generation from DDA results

- MRM / PRM panel generation from library

- Fragment ion refinement for PRM panels

- Improved performance for PRM

- Improved memory management

- Improved cache management

- Improved performance for loading / saving SPE files

- On-Click integration in XIC plots

- Data-completeness plot in post analysis

- CVs below X plot in post analysis

- Experiment overview grid in post analysis

- MS2 scan at apex plot for PRM

- Improved workflow for mixed analysis (MRM and PRM)

- Improved modification management

- Improved UI scalability

[Update 7.5.10300.4]

- Improved panel matching

- Minor bug fixes and improvements

大版本升级[Release Notes]What is new in SpectroDive 7.5?

- Support for Agilent instruments

- Improved performance for PRM workflows

- iRT refinement for PRM panels

- Miscellaneous minor bug fixes and improvements