[更新 11.14.240618.47784]

 - 允许在删除或排除片段后重新计算 Q 值

 - 排除片段时防止应用程序冻结

 - 添加新的报告字段 PEP.AbsoluteAmount、PG.AbsoluteAmount 和 EG.AbsoluteQuantificationMethod

 - 以线性比例添加新的报告字段 R.FileSize (MB) 和 R.MS1TIC

 - 添加新的报告字段 E.IdentificationStrategy 和 E.IdentificationThreshold

 - 增加前体和多肽数量折叠的最大选项

 - 允许在样品定量实验中报告校准曲线限值（LOD、LLOQ、ULOQ

 - 提示用户在执行片段选择细化之前重新提取原始 SureQuant 数据


[更新 11.13.240131.47784］

 - 允许 TimsTOF Pro 仪器导出 PRM 方法

 - 修正了分析后条件设置中错误的数量校正因子

 - 防止在样品定量后分析步骤中重新计算校准曲线

 - 修正了更改 XIC 边界时校准曲线图消失的问题 

 - 修复了基于参照的工作流程中过渡干扰得分缺失的问题

 - 修复了在报告视角中输出绝对量时忽略用户接受的错误

 - 修复了沃特斯 MRM 支持


[更新 11.12.231212.47784］

 - 修复了 11.12 中引入的错误，即没有处理校准曲线


[更新 11.12.231207.47784］

 - 修正了 QValue 报告中的差异

 - 为定标曲线图添加选项，以移除局部定量

 

 - 为校准曲线图添加选项，将 X 轴显示改为线性

 - 为校准曲线图添加选项，以移除标题中的定量范围

 - 修正了在校准曲线处理实验中，分析后更改设置会导致校准曲线平坦的错误

 - 使适用于分析后的设置可在分析后编辑


[更新 11.11.231110.47784］

 - 修复了某些情况下的软件激活问题


[更新 11.11.231018.47784］

 - 修复了离线激活的问题

 - 修复了 “分析后 ”视角中 “X ”以下 Cvs 图的缩放问题

 - 修复了 “分析 ”视角中缺失的 “采集概览 ”图


[小更新 11.10.230428.47784］

 - 修复了许可证过期系统的启动崩溃问题


[更新 11.9.230425.47784］

 - 将 .NET 版本从 5.0 更新至 6.0 

 - 修复了从库校准工作流程中峰值容量和 FWHM 丢失的问题

 

[更新 11.8.230330.47784］

- 修复了使用 Pulsar 生成库过程中的装配缺失错误


[更新 11.7.230316.47784］

 - 修正了高 DPI 系统中罕见的启动问题

 - 修正了较重元素 (> 氩) 质量表中的错误 (0.0 质量)

 - 修正了羟脯氨酸的定义

 - 修正了在修改面板中显示元素周期表的问题

 - 修正了校准曲线图的类别

 - 修正了多个实验的信息显示在错误的分析日志中的问题

 - 修复了 “准备 ”视角中 RT 校准消失的问题

 - 修复了创建 FAIMS-SureQuant 仪器方法时的罕见故障


 - 修复了在创建 FAIMS-SureQuant 仪器方法时出现的罕见故障

 - 添加了校准曲线特定的可报告元素

 - 新增 Pulsar 设置，将所有运行视为同一样本的馏分来生成文库

 - 点击校准曲线图点显示信息而不是悬停


改进面板生成向导：

 - 改进状态信息

 - 根据所有出现的蛋白质而非蛋白质推断进行蛋白质分组的新设置

 - 根据其他 FASTA 文件检查肽序列的新功能

 - 改进了分馏样本光谱库中肽段的丰度排序

 - 新增特定基因筛选和多肽分组功能

 - 添加了基于序列和蛋白质内位置的广泛肽段过滤功能


[更新 11.6.230131.47784］

 - 修复了空的 MS1/MS2 XIC 对齐图


[更新 11.5.221221.47784］

 - 确保导入或创建化验面板时显示在树形视图中

 - 修复了读取未计划的 prm-PASEF 文件的错误

 - 修复了在检测面板信息不完整的情况下丢失交叉运行图的错误


[更新 11.4.221128.47784］

 - 在 “运行 ”概览中显示正确的已确认化验数量

 - 修正了参比肽序列稀释校准曲线处理中的错误

 - 修复了 “分析 ”视角树形视图中显示已删除检测的错误

 - 在分析视角中添加了黄色条

 - 在使用不含离子迁移率信息的化验面板分析 prm-PASEF 数据时添加了警告功能

 - 在使用不含离子迁移率信息的检测面板分析 prm-PASEF 数据时添加了警告功能

 - 添加了对 FAIMS-SureQuant 的支持（分析文件和仪器方法导出）

 - 允许使用无空白的连续稀释数据处理校准曲线 - LOD 不可用

 - 修复用于布鲁克 TimsTOF 的 prm-PASEF 仪器方法导出中的错误

 - 修复定标曲线图与定量范围显示不正确的问题

 - 支持未计划的 prm-PASEF 仪器方法导出

 - 为基于定标曲线的绝对定量添加了量校正因子支持

 - 关闭校准曲线处理之外的校准曲线描述符报告


[Update 11.3.221103.47784]

- Added calibration curve linear fit descriptors

- Disabling clustering when there is not enough data points

[Update 11.2.221014.47784]

- Removed multiplexed information in Thermo QExactive instrument method output

- Allow deselection of "Show Legend" in MS1/MS2 Alignment plots


[Update 11.1.220930.47784]

- Added -command option to command-line interface

大版本升级[SpectroDive 11 - Release Notes]

New Absolute Quantification Workflow

 - Creation and visualization of calibration curves

 - Determination of limits of detection (LOD) and of quantification (LLOQ, ULOQ) 

 - Quantification of samples using calibration curves


Ion Mobility Support

 - FAIMS-PRM: analysis and method export

 - prm-PASEF: analysis and method export


Support for New Acquisition Methods

 - Hybrid-DIA: analysis and method export for targeted peptides


Improved Performance

 - Improved peak picking

 - Improved Pulsar search engine for panel generation


Improved User Experience and Visualization

 - Improved XIC Alignment plots with support for unlimited number of runs

 - Detachable perspective and plots for side-by-side visualization

 - Improved XIC grid overview plots

 - One-Click tree navigation in plots

 - Improved plot and tree filter selection

 - Quick-Action bar for analysis perspective

 - Improved UI for analysis log

 - New prm-PASEF mobilogram plot

 - Streamlined settings for clarity with new advanced category

 - Switched to a 2-color system for identification status annotation


[Update 10.7.220414.47784]

- Added saved experiment SPE saving from CLI

- Allow loading a settings schmema from name or file path in CLI

- Implemented quantity correction from samples conditions setup


[Update 10.6.220225.47784]

- Calculating number of removed assays in MRM

- Automatic upgrade and/or warning to save to new SPE file standard


[Update 10.5.211227.47784]

- Added scores for library fragments in refinement window

- Consistent date/time format for iRT calibration runs


[Update 10.3.210226.47784]

 - Significant improvement in RAM requirement

 - Changed default strategy for summarizing multiple survey runs by taking an average across peptide, instead of lowest

 - Updated manual


[Update 10.2.210120.47784]

 - Clean up of temporary files was not happening after closing a SureQuant experiment

- Improved loading performance for search archives using Pulsar for library generation

 - Added unpaired t-test strategy and made it default for regulation analysis

 - Improved fall back tolerances if automatic mass calibration did not have enough data points

 - New default option for spike-in workfow which requires identification of both target and reference channels

大版本升级[SpectroDive 10 - Release Notes]

Full Support for SureQuant Analysis

 - Support for method development for custom panels

 - Seamless data analysis with optimized peak picking for SureQuant acquisition

 - Post Analysis plots specifically for SureQuant acquisition


Improved False Discovery Rate Analysis

 - New decoy strategy for PRM and SureQuant

 - Reliable and automatic FDR for MRM, PRM and SureQuant analysis


Improved Performance

 - SpectroDive uses up to 30% less RAM than before


Library based PRM Scheduling

 - Import iRT calibration directly from a DDA or DIA spectral library for scheduling

 - Support for non-linear gradients


Improved Panel Support

 - Improved support for panel generation from library

 - Improved support for modifying an existing panel

 - Support for refining assays directly from a targeted analysis

 - Improved GUI for refining iRT and fragment selection


Library Generation 

 - View library settings in library perspective (for new libraries only) 

 - Improved identifications from deep learning augmented scoring with Pulsar

 - Added PD 2.4 support 


Other Features

 - New global settings for setting up SureQuant acquisition from a survey run

 - Mono-isotopic MS1 quantity is now reported for PRM and SureQuant

 - SpectroDive Viewer is available for browsing of already analyzed experiments

 - Various minor improvements in user experience

[Update 9.10.190923.41419]

 - Added interference score for transitions in the report perspective


[Update 9.6.190725.41419]

 - Added skip to last option for external panel import in prepare perspective to easily import panel as it is


[Update 9.5.190416.41419]

 - Added support for fill time correction in multipexed PRM


[Update 9.1.190401.41419]

- Added ability to sort runs by different criterias such as acqusition date, condition, etc.

大版本升级What is new in SpectroDive 9.0?

 - Improved panel generation workflow starting from spectral library

 - Support for non-linear gradient based inclusion list scheduling

 - Support for DDA or DIA based inclusion list scheduling

 - Improved PRM data analysis by using MS1 information

 - Pulsar database search engine integration

 - PQ500 human plasma panel support

 - MaxQuant.Live support

 - Improved wizard based experiment setup

 - Improved performance and memory management

[Bug Fixes 8.0.14288.5]

 - Switched to new MassLynxRawSDK API for Waters MRM data


[Bug Fixes 8.0.14288.4]

- Improved scaling for mirrored XIC chart in alignment view


[Bug Fixes 8.0.14288.3]

 - Added support to specify panel when setting up an experiment from command line prompt


[Bug Fixes 8.0.14288.1]

 - Added support for Xcalibur 4.0 method export 

 - Added support for Fusion PRM

 

大版本升级What is new in SpectroDive 8.0?

 - Library generation from DDA results

 - MRM / PRM panel generation from library

 - Fragment ion refinement for PRM panels

 - Improved performance for PRM

 - Improved memory management

 - Improved cache management

 - Improved performance for loading / saving SPE files

 - On-Click integration in XIC plots

 - Data-completeness plot in post analysis

 - CVs below X plot in post analysis

 - Experiment overview grid in post analysis

 - MS2 scan at apex plot for PRM

 - Improved workflow for mixed analysis (MRM and PRM)

 - Improved modification management

 - Improved UI scalability

[Update 7.5.10300.4]

  - Improved panel matching

  - Minor bug fixes and improvements


大版本升级[Release Notes]What is new in SpectroDive 7.5?

  -  Support for Agilent instruments

  -  Improved performance for PRM workflows

  -  iRT refinement for PRM panels

  -  Miscellaneous minor bug fixes and improvements