本期视频给大家介绍如何在悟空云平台实现混合物分析(BKMR)，该方法主要可以帮助大家解决变量之间存在高共线性的问题，可以作为变量筛选的一种参考方法，并且该方法还可以分析暴露变量和协变量之间的关系，查看他们之间的相互影响。该模块是由我们QQ交流群的一位小伙伴建议搭建，还是挺有意思的，感兴趣的可以来看看是否可以应用到你的课题当中。本系列视频会收录在我们公众号菜单：技术动态->悟空云系列讲座


视频内容请通过页面中的“核对公众号原文”观看。
使用悟空云平台，可在文章中如下描述：

 1) 比如在正文Methods部分：We use 'Wu Kong' platform (https://www.omicsolution.com/wkomics/main/) for relative xxx analysis.

    2) 比如在致谢(Acknowledgements)部分：Thank Dr. Shisheng Wang (West China Hospital, Sichuan University) and Dr. Chengpin Shen (Omicsolution Co., Ltd) for giving some advices about data analysis and 'Wu Kong' platform (https://www.omicsolution.com/wkomics/main/) for relative xxx analysis.


目前基于悟空平台开发的分析工具已发表以下文章：


    1. (2020) Shisheng Wang , Wenxue Li, Liqiang Hu, Jingqiu Cheng, Hao Yang, Yansheng Liu, NAguideR: performing and prioritizing missing value imputations for consistent bottom-up proteomic analyses, Nucleic Acids Research, gkaa498. (2021 IF: 19.16). Link to article.

    2. (2022) Huilin Yu, Haiyu Luo, Luping Chang, Shisheng Wang （共一作） , ..., Hao Yang, Wenying Fan & Bing-Qiao Zhao, The NEDD8-activating enzyme inhibitor MLN4924 reduces ischemic brain injury in mice. Proceedings of the National Academy of Sciences, 119(6). (2021 IF: 12.779). Link to article.

    3. (2022) Yi Zhong Shisheng Wang (共通讯) , et al. Proteome and phosphoproteome profiling of non-small cell lung cancer cell line A549 treated with TRAIL, Proteomics, 10.1002/pmic.202200248. (2021 IF: 5.393). Link to article.

    4. (2021) Shisheng Wang , et al. StatsPro: Systematic integration and evaluation of statistical approaches for detecting differential expression in label-free quantitative proteomics, Journal of Proteomics, 10.1016/j.jprot.2021.104386. (2020 IF: 4.04). Link to article.

    5. (2021) Shisheng Wang , Yi Zhong, Jingqiu Cheng, Hao Yang, EnrichVisBox: A Versatile and Powerful Web Toolbox for Visualizing Complex Functional Enrichment Results of Omics Data, Journal of computational biology, 10.1089/cmb.2020.0564. (2020 IF: 1.479). Link to article.

    6. (2020) Shisheng Wang , Hongwen Zhu, Hu Zhou, Jingqiu Cheng and Hao Yang. MSpectraAI: a powerful platform for deciphering proteome profiling of multi-tumor mass spectrometry data by using deep neural networks. BMC Bioinformatics 21, 439 (2020). (2019 IF: 3.242). Link to article.

    7. (2019) Shisheng Wang , Yue Cai, Jingqiu Cheng, Wenxue Li, Yansheng Liu and Hao Yang. motifeR: An Integrated Web Software for Identification and Visualization of Protein Post‐Translational Modification Motifs. Proteomics: 201900245. (2018 IF: 3.106). Link to article.

    8. (2019) Shisheng Wang and Hao Yang. pseudoQC: A Regression‐Based Simulation Software for Correction and Normalization of Complex Metabolomics and Proteomics Datasets. Proteomics: 1900264. (2018 IF: 3.106). Link to article.

    9. (2018) Shisheng Wang , ..., and Meng Gong. MetaboGroupS: A Group Entropy-Based Web Platform for Evaluating Normalization Methods in Blood Metabolomics Data from Maintenance Hemodialysis Patients. Anal Chem 90, 11124-11130. (2017 IF: 6.042). Link to article.

    10. (2018) Shisheng Wang , ..., and Hao Yang. MixProTool: A Powerful and Comprehensive Web Tool for Analyzing and Visualizing Multigroup Proteomics Data. Journal of computational biology : a journal of computational molecular cell biology 25, 1123-1127. (2017 IF: 1.191). Link to article.

    11. (2018) Qing-Run Li, Shi-Sheng Wang(共一作) , Hong-Wen Zhu, Fang-Ying Xia, Peter Roepstorff, Jia-Rui Wu, and Rong Zeng. Data-Independent Acquisition Mass Spectrometry to Localize Phosphosites. bioRxiv: 464545. Link to article.

同时悟空平台整合上百个分析模块，包括且远不止以下功能


而围绕上游质谱数据解析和下游组学应用，易算近期也发表了多篇文章：

    • DeepFLR facilitates false localization rate control in phosphoproteomics

      Y.Zong, Y.Wang, Y.Yang, D.Zhao, Xiaoqing Wang, Chengpin Shen, and Liang Qiao*  Nature Communications IF18,2023

    • Data-independent acquisition boosts quantitative metaproteomics for deep characterization of gut microbiota
      J. Zhao, Y.Yang, H.Xu,..., Chengpin Shen,.. Xia Li* and Liang Qiao* npj Biofilms and Microbiomes IF8,2023

    • Circulating proteomic panels for risk stratification of intracranial aneurysm and its rupture

      Yueting Xiong, ...,Xiaohui Liu*   EMBO Mol Med, IF12.3,2022

    • Multi-Omic Profiling of Multi-Biosamples Reveals the Role of Amino Acid and Nucleotide Metabolism in Endometrial Cancer

      Runqiu Yi, Liying Xie, Xiaoqing Wang, Chengpin Shen, Xiaojun Chen*, Liang Qiao*，Frontiers in Oncology，IF6.3,2022

    • Mesoporous Silica as Sorbents and Enzymatic Nanoreactors for Microbial Membrane Proteomics 
      J. Zhao, R. Jian, Y. Wang, B. Yang, D. Zhao, C. Shen, L. Qiao*, B. Liu*, ACS Applied Materials & Interfaces, IF10,2021

    • Direct MALDI-TOF Profiling of Gingival Crevicular Fluid Sediments for Periodontitis Diagnosis
      J. Yi, Y. Shen, Y. Yang, C. Shen, B. Liu, L. Qiao*, Y. Wang*, Talanta, IF5,2021

    • Proteomic and Metabolic Elucidation of Solar-Powered Biomanufacturing by Bio-Abiotic Hybrid System
      Rutan Zhang, ..., Chengpin Shen, ..., Liang Qiao  Chem IF26,2020

    • In silico spectral libraries by deep learning facilitate data-independent acquisition proteomics
      Yi Yang, ...,Chengpin Shen,... and Liang Qiao  Nature Communications IF18,2020

    • Metaproteomics characterizes human gut microbiome function in colorectal cancer
      Shuping Long, ..., Chengpin Shen,.. and Liang Qiao npj Biofilms and Microbiomes IF8,2020



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